Irina Ianculescu, Ph.D.

Dr. Ianculescu received her PhD in Genetic, Molecular and Cellular Biology from the University of Southern California. Her doctoral dissertation focused on the role of histone acetyltransferases in androgen receptor mediated transcription in prostate cancer cells. She has over ten years experience applying molecular biology techniques to the understanding and treatment of various diseases including cancer and diabetes.

Education

University of Southern California, Los Angeles, CA

• Ph.D.- Genetic, Molecular and Cellular Biology 2011

Occidental College, Los Angeles, CA

• B.A.- Cell and Molecular Biology 2000

Publications

Ianculescu I, Wu DY, Siegmund KD, and Stallcup MR. 2012 Selective Roles for CBP and p300 as Coregulators for Androgen-Regulated Gene Expression. J Biol Chem 287(6):4000 – 13.

Ou CY, LaBonte MJ, Manegold PC, So AYL, Ianculescu I, Gerke DS, Yamamoto KR, Ladner RD, Kahn M, Kim JH and Stallcup MR.2011. A coactivator role of CARM1 for the dysregulated b-catenin activity in colorectal cancer cell growth and gene expression. Mol Can Res 9(5):660-70.

Lee DY, Ianculescu I, Purcell D, Zhang X, Cheng X, Stallcup MR. 2007 Surface scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function. Mol Endocrinol 21(6):1381-93.

Shan L, Vincent J, Brunzelle JS, Dussault I, Lin M, Ianculescu I, Sherman MA, Forman BM, Fernandez EJ 2004 Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism. Mol Cell 16(6):907-17.